Leon's next game appearance depicts him as an 'Anti-Umbrella' agent in the non-canon Resident Evil Gaiden, an alternate universe gaiden installment released for the Game Boy Color. Likewise, in Code: Veronica, Claire gets in touch with Leon when she is trapped on Rockfort Island, and in turn, Leon relays her information to Chris.

In Survivor, he is mentioned to be the one who sent the game's protagonist, Ark Thompson, to go undercover into Sheena Island (the game's setting). In Resident Evil: Survivor and Resident Evil Code: Veronica we learn that Leon has joined an 'Anti-Umbrella' force. Military, and Leon made an undisclosed deal with a representative of the U.S. After escaping the city, Claire set out on her own to search for her brother, while Leon and Sherry were approached by the U.S.

The epilogues of Resident Evil 3: Nemesis expand on Leon's fate following Resident Evil 2. However, Ada is fatally wounded and presumed dead, leaving Leon to escape the lab by himself along with Claire and Sherry. Just prior to making his escape, Leon learns that Ada is actually a corporate spy sent to steal the G-Virus. His attempt to find an escape route leads to Umbrella's underground laboratory within the city, where he confronts several of Umbrella's mutant creatures, including a mutated William Birkin. He maintains radio contact with Claire and is partnered with Ada Wong, a woman claiming to be looking for her missing fiancee.

The two decide to seek refuge in the city's police station, as they attempt to escape the city alive. He finds the town already overrun by zombies and encounters another living civilian, Claire. He arrives late to Raccoon City on his first day of duty, already dressed in the armored R.P.D. In the story, Leon is a recently-hired police officer for the Raccoon Police Department. Leon is one of the two leading characters featured in Resident Evil 2 the other being Claire Redfield.

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